George, dont know if you went for a Registry cleaner but you might look at Easy Cleaner
http://www.download.com/ToniArts-EasyCl ... 29179.html
D/L thru the CNet site & pretty well recommended. Also look for CCleaner. Both are good maintenance utilities and
free. I use both - they always find different stuff, but the little bitty differences dont mean diddly. Dan is right (as always) - BACK UP BEFORE CHANGING. The registry is the Achilles heel of Windows - the only real way to clean it is to reformat the HD, re-install Windows and then all your software.
I also use two different defraggers - JKdefrag and Auslogics disk Defrag. JK runs longer but does a slightly more thorough job.
My weekly routine is to use CCleaner and/or EasyCleaner to clear out the 'junk', then use the Registry cleaner(s), then run the defragger(s). And I keep the start-up list as short as possible.