Are you going to build your own Gene? If so, just make sure the case has good ventilation. Normally the only fan for the case is on the power supply as the video card and most CPUs have their own fans. As long as the CPU has an attached cooling fan and heat sink, and the case hase good ventilation, you should be okay. Some cases have provisions for additional cooling fans that are triggered by temperature.
Most fans don't make enough noise to be bothersome. The fan on my original video card (nVidia Quadro FX540) started getting real noisy and Dell replaced the card. The new one is completely silent.
If you want to post your configuration I'll be happy to take a look at it and see if extra cooling is needed.
Having replaced the case on my main PC just a few months back I can tell you that the new cases have much better cooling. I replaced my case because the PC was overheating. The new cases alone come with 2 or 3 five inch fans - one in the back, one in the front and one in the side. That's besides the one on the CPU, the one on the power supply and the one on the video card. My PC only has 5 fans. It's actually pretty quite since most of these are setup to run in response to the temperature. The more fans in there the slower they all seem to be running, and the quieter it seems.
One case I did have a problem with was made by a company called Cooler Master. It was setup with something like 4 fans, and it was configured such that it was impossible to connect the motherboard to the power supply. It was of course returned.